TBH if you want to do that many players just make it a Forum Game. They're easier to split up and are designed to take multiple days anyway. I'm not a super-experienced host or anything I wouldn't be as helpful as some of the other people in the Lobby, but I think that it would be nearly impossible to make any sort of game that revolves around that many schedules.
Just to expand upon what Alec is saying, I would never go above 24 people without a cohost, even if you're the most experienced host in the lobby.
I agree with alec. You definitely should get a lot of experience hosting before you even think about hosting something of this magnitude. And by a lot I don't mean like 10 little games.
I would advise anyone––before they try hosting on such a large scale––to gain more hosting/playing experience. If you feel that's not necessary, you can totally go ahead and try it.
@Bob01 I second that.
I agree with bob here that it's very difficult to organize games around the schedules of 30+ people.
The thing about splitting the game up over many days is that someone could be in the game, but they might not be able to come for the next day.